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Lying awake at 3 AM, staring at the ceiling, can feel endless. When sleeplessness lasts for days and affects daily life, doctors may prescribe short-term medication to restore rest. In the UK, sometimes Nitrazepam tablets also known as Mogadon are prescribed for severe insomnia lasting only short-term.
This mighty benzodiazepine aids the adjustment of sleep cycles but is not a permanent solution. Due to its high potency and associated risks, it is very important to dazzle how it operates, the correct dosage, and the possible side effects before the commencement of the treatment. If used correctly and under supervision, it can be a quick-fix solution for the problem of sleeplessness if it is not overused.
Nitrazepam is put in a group of drugs known as hypnotics, and the main purpose of these drugs is to put a person to sleep. It is a member of the benzodiazepine family, which are characterized by their strong sedative and calming effects on the brain and central nervous system.
The GABA (gamma-aminobutyric acid) is a naturally occurring chemical in the brain that plays a crucial role in Nitrazepam's effect. GABA acts as a natural brake, causing a reduction in the nerve activity that is excessive. In case your brain is too lively or 'wired' when you attempt to sleep, GABA will not be able to function perfectly.
Nitrazepam leads to the GABA effects being magnified. One could picture it as giving a strong push to the brain's naturally calming messenger. The drug is now an even stronger ally for GABA in this calming role; thus, it is able to make relaxation of the brain occur more easily. Hence, sleep comes quickly, the duration of sleep increases, and the quality of sleep becomes a peaceful night. It has a very strong sedative effect but it also possesses other actions, like giving relief from anxiety, and relaxation of muscles. Because of the drug's relatively long duration of activity (it takes some time for the body to completely get rid of it), the calming effect is felt throughout the night, which helps avoid those annoying and frequent awakenings during the night.
Nitrazepam is not an easy drug to get since it is practically the last drug for sleep issues, only given when insomnia is at its worst, paralyzing, and taking away much of a person's quality of life.
Its application is primarily the management of insomnia with the following problems:
Difficulty in getting to sleep: When you can't seem to fall asleep for a long time after going to bed.
Waking up too often at night: This is when you are waking up several times during the night.
Waking up very early: This is when you are up way too soon and cannot go back to sleep.
Doctors consider the use of Nitrazepam as a last resort measure. On this account, it is a very powerful drug that can quickly end a sleepless streak and let the individual recharge their mind and body. However, it is neither a permanent solution nor a recommended one since its potency diminishes over time while the hazards go up astronomically.
The prescription may be given for a few days, or in rare instances, for a maximum of four weeks, just to help you through a difficult period of intense stress or sleep loss due to crisis. In some rare cases, it may also be prescribed for certain types of seizures, but its primary application remains that of a potent sleep redeemer.
Due to its strong effects, the use of Nitrazepam necessitates strict compliance with the physician's directions. The main rule is always to apply the minimum effective dose for the least amount of time.
The usual starting dose for most adult patients is 5 mg, taken at once daily. If your doctor thinks the initial lower dose is ineffective, he/she may decide to raise it to a maximum of 10 mg.
Timing is key: Take your pill at about the same time as you go to bed. As it works quite fast (normally within 30 to 60 minutes) and it has a long-lasting effect, you have to see that you get at least 7 to 8 hours for sleep. Taking it earlier might cause too much sleepiness before going to bed and taking it when you do not have enough sleep time will surely lead to a severe 'hangover effect' the next morning.
Elderly patients: The aged are usually more vulnerable to the effects of sedatives which can result in confusion, dizziness and falling down. This is why the initial dosage for the elderly is generally much lower, often 2.5 mg, and rarely goes above 5 mg.
Never increase the dose: Never increase the prescribed dose, even if you think it is not as effective as before. If you feel it has become less effective, you should talk to your doctor, as this may be a sign of tolerance.
Like any strong medicine, Nitrazepam can produce adverse effects. These may be as mild, usual annoyances up to rare, very serious, life-threatening situations.
The effects that have been reported most are the ones connected to the sleeping-sedative property of the drug, and they are usually temporary:
Daytime drowsiness (The Hangover Effect): As the drug has a long half-life (it maintains a prolonged presence in the body), it is quite common to feel tired, sluggish, or faint the next day.
Dizziness and unsteadiness: This impacts your sense of balance and coordination and that will increase your chances falling, especially among older people.
Impaired coordination: It may seem like you are losing your balance or having problems with little tasks that need delicate control.
Reduced alertness: You might experience slower reactions and lesser concentration.
Headaches
Confusion or memory issues: Being foggy-minded or going through a temporary situation where you can't recall things that happened post-take of the tablet (known as anterograde amnesia).
Although uncommon, some side effects are more serious and ask for immediate medical attention:
Paradoxical reactions: In some cases, especially among children and patients with personality disorders, benzodiazepines might lead to the opposite effect - thereby causing non-compliance with the medication resulting in the patient being agitated, aggressive, excited, restless or having worsened insomnia.
Complex sleep behaviours: Although very rarely, people may be engaged in activities that they are not entirely awake for, such as 'sleep-driving,' calling someone, or eating and later on have no recollection of the events.
Severe allergic reaction: A serious allergic reaction may show up through facial, lip, tongue, or throat swelling and/or breathing problems.
Nitrazepam is a strong and powerful drug for the short-term management of acute insomnia. It is a means to cut off a difficult cycle of not being able to sleep and get back the required rest. Nevertheless, it is a potent substance that needs to be handled very carefully and with full understanding of its effects.
Dosing has to be done according to the doctor's prescription, and a commitment to living in ways that help sleep naturally has to accompany this usage. Always consider Nitrazepam as a precious short-term tool and always keep a communication with your doctor that is open and honest concerning your sleeping progress and any side effects you may suffer. Your health and safety will be determined by it.