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His research was aimed at finding a new and safer medicine for the treatment of various pain related conditions. Pregabalin gained FDA approval in 2004. It is widely used today, and its broad range of applications makes it invaluable for patients.
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Pregabalin, as an anxiolytic, analgesic and anticonvulsant medication, provides a dependable option for addressing a range of health conditions. Its anticonvulsant properties make it ideal for treating seizures and epilepsy. The analgesic action relieves moderate to severe pain including neuropathic pain.
The anxiolytic effect helps deal with conditions such as anxiety disorders and restless leg syndrome. Studies reveal that approximately 8 million UK residents experience anxiety disorders, and about 6% of the population in Europe. To have access to a proper and reliable medication has become a necessity.
Pregabalin treats a very wide variety of anxiety disorders, these include general anxiety disorder (GAD), social anxiety disorder, post-traumatic stress disorder (PTSD), panic attacks as well as different phobia's. Its ability to promote a sense of calm helps alleviate these all too common conditions.
The starting dose for pregabalin is set for every patient separately. The first dose for the treatment of neuropathic pain is 300mg daily and can then be increased to 450mg (but never exceed 600mg) to meet the necessary requirements. For anxiety, the general recommended dosage should be lower, but still determined by a medical professional.
It's very important to strictly observe the recommended pregabalin dosage and any other instructions the user is given for the best therapeutic benefits. Any concerns or side effects should be reported to your general practitioner as soon as they arise.
Healthy lifestyle changes can improve your overall well-being if you are suffering from anxiety, seizures or pain. To improve general health, begin the day with mindfulness exercises, like meditation or deep breathing, to relieve anxiousness. In the afternoon or evening, about 30 minutes of light exercise will help.
Usage instructions for pregabalin will be provided by the medical consultant and should be followed carefully. This ensure safe and effective usage. The drug can be administered with or without food, but is best taken with a light meal. Some patients, especially predisposed to dangerous conditions, should be observed closely for adverse reactions when they start the medicine.
For neuropathic pain conditions, general recommendations for the initial dose is 300mg daily, which can be gradually increased if needed, under supervision. For the treatment of generalized anxiety disorder, the initial dose is usually lower and should also be determined by the GP.
The set pregabalin dosage must be carefully observed to rule out any side effects. If the treatment must be stopped for some reason, do not stop it abruptly, as it may cause withdrawal effects. Instead, consult with your healthcare practitioner and taper off the drug slowly and carefully.
The onset of action differs, and the first few doses might be less effective. For most users, the medication will take effect in the first day or two of treatment however this can take longer. It might take a week of constant consumption for any desirable results to be evidently seen. Individual experiences might be different.
The full value of therapy becomes apparent after some time. This is why users should not exceed the dosage if it seems like the medicine is not having an effect over the first few days. Patients need to keep calm during the first stages, understanding that the positive results will be achieved when the active component builds up in the body.
Following a specific therapy scheme often is a decisive factor for pregabalin to work properly. It can alleviate the adverse manifestations of this drug, while keeping it safe for the user at the minimum effective dose.
Users should bear in mind that it's best to completely abstain from taking any alcohol or other substances that slow the central nervous system while on this medication. Alcohol is a depressant and combining it with these pills might cause too much sedation, which is dangerous.
One drug interaction with pregabalin that raises the risk of respiratory depression can come as a result of combining it with benzodiazepines. Besides the possibly adverse substances mentioned earlier in this article, make sure you inform your prescribing doctor about the drugs you are taking to avoid unwanted reactions.
A professional consultant can guide you through the treatment, adjust the dosage or suggest an alternative way to deal with your concerns. Observe the dosage and strictly avoid double-dosing. If a dose is forgotten do not compensate for it, instead carry on with your schedule and take the next one when it is time.
As a rule, the pregabalin half-life is generally 6.3 hours. In this context, the half-life is a time interval required for the body to discharge approximately half of the drug from its system. It is not the same for everyone. Many variables, including various conditions, liver function and overall health, may considerably affect how fast pregabalin is processed.
Pregabalin can be detected in urine for more than 5-6 days after a dose is taken. It will show up in blood tests for 1-2 days. Traces of it can remain in hair follicles for up to three months, and can be detected with some tests.
Pregabalin may be accompanied by a number of side effects. They can manifest as vertigo, nausea or a bout of confusion. Some people may observe increased weight, especially if they tend to eat compulsively, as pregabalin sometimes makes the user hungry.
According to the NHS, these mild side effects will appear in 1 user in about every 100. There are also more severe possible reactions, which are much rarer and demand medical attention. Those include severe dizziness, passing out and mood changes.
There are techniques to reduce the likelihood of side effects and deal with the ones that appear. Proper hydration (drinking 2 – 3 litres of water a day) can help with many of the mild side effects. Regular light exercise, such as about 30 minutes a day of low-intensity training, can also work well to decrease anxiety and deal with insomnia, complementing the medicine.
A varied diet with plenty of vegetables and fibre can go a long way in helping to avoid side effects, as it helps the body get vital nutrients that it might be missing.
Pregabalin has been subjected to extensive research and rigorous clinical trials before it was approved for the market to confirm that it is safe and efficient as a medicine. Research by academic teams independent from regulators is also widely available online and confirms the excellent safety profile of pregabalin.
This process included a thorough scrutiny of side effects, careful comparison with placebo groups to establish efficacy and analysis of how the different patient groups responded to the treatment. The strict procedures and protocols that regulators follow ensures drugs are only approved after being deemed safe for the public.
The approval of pregabalin by regulators in all developed countries confirms that the treatment is low-risk and reliable, and so does its wide use. According to the UK Pharmaceutical Journal, some 10.3 million prescriptions for the treatment were issued last year in Britain, as opposed to 8.7 million in 2019. The fact that prescriptions are in the millions and growing confirms that UK doctors trust this treatment.
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Last Reviewed: 15th October 2024
Next Review Due: November 2025
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