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Tapentadol, also known as Palexia or Nucynta, is a strong analgesic. It is a licensed and approved treatment adhering to the highest quality and safety standards. Classified as an opioid medicine, it was first synthesised in the 1980s on the basis of another well-known treatment, tramadol, at Germany's Grünenthal labs.
Tapentadol is a medicine used for many conditions and widely applied by UK doctors, but mainly prescribed for strong pain. It is safe when used correctly as proven by clinical testing, but some precautions are required when starting and taking it. We will cover those safety rules in the subsequent sections.
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Tapentadol is a strong analgesic that is typically used to relieve moderate to severe pain. It is prescribed when non-opioid pain relievers are ineffective or not well-tolerated. Severe pain may be a result of an injury, surgery, or a chronic condition like nerve damage. It can manifest as different sensations.
Acute pain affects nearly 10 million people in the UK annually. Resulting from things like broken bones, toothache, accidents and injury, it is often the result of trauma or surgery, which are normal parts of everyday life. Then there are the chronic conditions, like musculoskeletal or neuropathic pain, caused by the body's systems malfunctioning.
According to the NHS, a staggering 20 million UK residents are affected by persistent pain in bones, joints, and muscles. This type of pain is called musculoskeletal and can be caused by conditions like arthritis. The fact it affects close to a third of the United Kingdom's population shows us the importance of access to treatment.
The type of condition being dealt with will shape the whole tapentadol treatment plan, as the time frames can vary for different ailments. This is what makes it important to consult with a GP before taking this medicine for the first time, to set the dosage and schedule.
Proper and effective pain management with this medicine is based on getting the dosage right and then following it. The dosage with tapentadol should be set by a GP or other consulting doctor based on the user's medical history and current condition.
As recommended in NHS guidelines, the usual starting dose of the treatment for adults is 25-50 mg per day. This is usually increased to 50-100 mg tapentadol after about two weeks of use. The dosage is to be changed gradually, in accordance with the doctor's instructions.
Strictly adhering to their advice is important with this opioid treatment. Another aspect of a healthy experience with tapentadol is for the user to make some changes to their lifestyle. A healthy lifestyle will supplement this medication and help the user in managing chronic pain better.
Users should do regular gentle exercise like low-impact physical activity and stretches, which will have a positive effect on health in any conditions. A nutritious and balanced diet will also support health and aid recovery.
Drinking plenty of water helps bodily functions and could help overcome some side effects of the treatment. The body's healing processes require optimal sleep, so users should not forget about sleep hygiene.
This medicine works centrally on the nervous system and has a double action. One aspect of it is that when the treatment is metabolised in the body, the resulting substance binds to mu-opioid brain receptors and alters the way pain signals are perceived by the brain.
The other part of its action is that it works as a norepinephrine reuptake inhibitor, which serves to increase the effects of that neurotransmitter and also helps alleviate pain symptoms. This double action of tapentadol is unique. It is one of the things that make this medicine so effective for pain.
The medicine is also recognised as a weak serotonin reuptake inhibitor, but this does not significantly add to its effects as a painkiller. Overall, the treatment is a universal, strong and fast-acting drug that relieves pain symptoms effectively.
The tapentadol effect is usually felt in about 30-60 minutes after the medicine is taken. The subjective response could always be different, as there are many factors like metabolism, condition severity, and the overall health of the user to consider.
The advised dosage and directions that the doctor provides should be followed at all times, as this is the best way to maximise safe usage. If tapentadol does not seem to be having an effect after consumption, the user must not take more. Instead, report the perceived lack of effect to the doctor and continue with treatment as normal.
It's important not to double-dose at any time, as there are some possible side effects that could be triggered. If they manifest, they should be reported to the consulting physician. These side effects will be covered in a subsequent section.
Taking tapentadol simultaneously with other opioid drugs is one of the main contraindications to it, and should be avoided. The effects might combine to cause too much sedation and even respiratory depression, which could be dangerous.
The same applies to alcohol, as it has depressant effects as well. Alcohol in combination with the treatment will increase central nervous system depression, heighten the feeling of drowsiness and impair coordination further. There are also some conditions that might be affected by this medicine, and users suffering from them must take it with caution.
Mention any pre-existing conditions or current medications to the doctor before commencing treatment. Among them are gastrointestinal obstructions, asthma or other drug problems. If the prospective user is pregnant, she should avoid using this treatment and opioids in general.
The half-life is a drug is the time required for a half-portion of the drug to be removed from the body after a dose is taken. With tapentadol it is normally about 4 hours. When the drug is stopped, it normally takes up to 20 hours to leave the system completely. Drug elimination times may vary among people due to different metabolism rates and other individual factors.
Tapentadol is excreted through the kidneys, so people with certain health conditions, like renal impairment, should first receive approval from their doctor about tapentadol use. Compared to other drugs in its class, the treatment is processed fairly quickly. The half-life of tramadol, for instance, and fentanyl can stay in the body for up to seven hours.
The medicine can cause side effects. Although they are rare and most users never experience a negative reaction it is important to be on the lookout for side effects. For the most part, users can minimise the exposure to side effects by strictly adhering to the dosage instructions. Tapentadol side effects are divided into mild and severe ones, with the former being more common.
The potential mild side effects with this medicine include constipation, which is partly alleviated by drinking water. Another such effect is nausea, for which the NHS guidelines recommend consuming water in small sips. Joint pain, swelling or persistent dizziness with tapentadol are among the rare adverse reactions that should be reported to a doctor. If the user is feeling dizzy, they should wait until it passes before they engage in activities that need concentration.
This treatment is recognized and approved by UK authorities for use after extensive studies and research. Clinical trials have repeatedly proven its efficacy and safety when taken for pain management. If we look at studies, they confirm tapentadol is safer than other opioids. A recent meta-study published in the Journal of Pain Research, for instance, confirms that the risk of gastrointestinal reactions with this medicine is much lower than with other treatments of its class. Its authors note separately that this treatment is safe for long-term use.
Users can be assured of the reliability and safety of tapentadol, confirmed in many clinical trials in various countries. There is some potential for abuse of the drug, but, as confirmed by several papers based on data from the RADARS (Researched Abuse Diversion and Addiction-Related Surveillance), the risk is markedly lower than with other similar medicines.
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Last Reviewed: 15th October 2024
Next Review Due: November 2025
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