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Ultram and Maxitram are the brands for this commonly prescribed medication. Belonging to the opioid analgesic family, tramadol works by changing the way the central nervous system responds to pain. It was originally introduced to the market in 1977, following testing, licensing and approval.
Clinical studies conducted on this active ingredient for nearly 50 years confirm its good safety profile and efficacy for treating even the most severe pain. It is prescribed when other treatments are not enough or not suitable.
Do you already know what medication you need and want to save money by shopping online? Perhaps you are recovering from an accident or injury and need a stronger painkiller? Whatever your situation, follow along as we delve deeper into the world of tramadol and find out why people turn to this strong painkiller in their hour of need.
This is a reliable medicine indicated for conditions that result in moderate to severe pain, both acute and chronic. Both are prevalent in the UK, but surveys show that chronic pain is a major health concern that affects a large part of the population.
Over twenty million people in Britain, or about one third of UK adults, report experiencing chronic pain on a regular basis. The causes can range from back conditions and migraines to ailments like fibromyalgia and arthritis.
Acute pain is reportedly experienced by 10 million UK residents annually. It can be the result of an accident, injury or a surgery. Various types of pain are widespread, and the importance of medications like tramadol is confirmed by their wide use, as millions of UK residents are prescribed opioid painkillers each year.
When used correctly, this medicine can improve the lives of a great number of people living with chronic pain. Delivery options grant even more benefits, as they help those with limited mobility caused by pain receive their medicine easily.
As per NHS recommendations, the dosage of tramadol for acute pain has to be determined by a healthcare practitioner. It is usually prescribed within the UK system for pain that is expected to last a short time. The user may be told to take the medicine as they need, i.e. when the pain sets in.
The usual dose, as recommended in the UK tramadol information leaflet, is one to two 50mg capsules up to four times a day, or every 4-6 hours. The maximum daily dose, which should not be exceeded, is set at 400mg. These guidelines should be used by doctors to determine the exact dosage for each prospective tramadol user.
The dosage set by the medical consultant must not be exceeded in order to avoid the side effects. When it is adjusted, this should be done only by a competent medical worker. The adjustment should be gradual, as rapid changes to dosage may lead to adverse effects.
Mindfulness techniques, such as meditation or yoga, to complement medicine like tramadol, can be used to manage pain better. This helps minimise the stress and psychological consequences of the condition.
Tramadol should be taken orally, on an empty stomach or with a meal. In the case of extended release tablets, they should not be crushed or chewed, as this will lead to the active ingredient being released too quickly.
One thing to avoid is double dosing. With the immediate release tablets, one should not take a dose outside of the schedule to compensate for one they forgot. Otherwise, a lot will depend on the formulation, whether it is extended, or modified release. However, in no case should two doses be taken at the same time.
Tramadol can be taken at any time, but it is a good idea to take the doses around the same time and space them evenly throughout the day. A visualised treatment plan can be useful to prevent skipping doses.
The answer to this question should be given by a healthcare practitioner in each case. Usually, the dosage prescribed is one 50 mg pill every 4-6 hours, but there are some circumstances in which the dosage is increased.
I could be increased on the doctor's order if the user is not feeling enough of an effect. The dose is quite often reviewed after several weeks of use as the medication takes effect and tolerance builds up somewhat in the user.
This can only be done gradually, with the doctor's approval. Taking more than the recommended dose may provoke an adverse reaction. To avoid that, the user must never take the matter of dosage adjustment in their own hands.
The effect generally starts to be seen around 30 to 60 minutes after ingestion. This time frame might be different, depending on things like individual metabolic rates, the concurrent use of other medicines, and the kind of drug formulation being taken.
The fast-acting pills lead to quicker pain relief while the other formulas have a slow onset, but the action lasts longer. Various tramadol formulations are best suited for different conditions, and, overall, the course will be largely shaped by what formulation is prescribed.
Tramadol must not be combined with other sedative substances that act on the central nervous system, such as alcohol, sedatives, tranquilizers, or other opioid medicines. Their effects can combine and cause too much sedation, which is dangerous.
A person taking monoamine oxidase inhibitors (MAOIs), or other drugs that work on the serotonin system, may encounter serotonin syndrome, where the symptoms may range from blurred vision and confusion to muscle spasms, fever and high blood pressure.
People suffering from kidney or liver problems, head injuries, any conditions that cause seizures or fits, disorders like depression, or other mental ailments, should approach the medication with care. This list is not complete, and users are encouraged to study the contraindications in full using authoritative sources such as the BNF website if they are in the UK.
Tramadol has a half-life of 5-6 hours, which is longer than most medicines of its class. When tramadol is taken, it is actually broken down in the body into at least 23 different metabolites. Some of them can still be detected in different parts of the body much later on.
The medicine can usually still be picked up in urine for 2-4 days after the last dose has been administered. The metabolism, liver function, and hydration levels of the users will play an important role in how long it lasts. Hair follicles might contain metabolites of tramadol for up to several months.
The medication can potentially lead to adverse effects. The most common side effects of tramadol are headaches, sleepiness and nausea. The sleepiness should wear off by itself, while for gastrointestinal problems it might help to avoid fatty and spicy foods. It could also help to take it after a light meal or snack. Constipation is another possible light side effect that can be addressed by eating more fibre.
Serious side effects will occur in about 1 in every 100 users, according to the NHS. One of them is respiratory depression, which could be brought about by not observing the contraindications or exceeding the dose. This requires immediate medical attention.
Another serious side effect is an allergic reaction. Users must be carefully monitored when they start with this medicine for any signs of it, such as swelling of the mouth. If they emerge, users should report them to a doctor as soon as possible.
Before getting legal approval and regulator licenses in the UK, tramadol underwent intensive trials for safety and efficacy. Over decades of its use, its safety profile has been studied dozens of times by regulators and independent researches in various groups of patients.
Tramadol has been placed on essential medicines lists in many countries all over the world. Although it is also regulated by many of those countries, prescriptions in developed nations remain in the millions. The fact that it is so widely used confirms its safety, and the results of many clinical trials of tramadol are published online, also reinforcing its standing as a safe drug. They confirm the very low incidence of serious side effects in users, although light symptoms like nausea are experienced relatively often.
Side effects are still possible, and every user's situation should be studied and evaluated. For instance, some users are known to be ‘ultra-metabolisers', which means they metabolise tramadol very swiftly, resulting in very strong effect even with an average dose. Others will practically refuse to metabolise tramadol. The rate of metabolisation is largely determined by genetics.
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Last Reviewed: 15th October 2024
Next Review Due: November 2025
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