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Also known under the brand name DHC Continus, this medication was first developed in Germany in 1908. Dihydrocodeine is classified as a semi-synthetic opioid analgesic and has proven to be a reliable medicine commonly prescribed in the UK since 1911. It is used to treat pain-related conditions when non-opioid analgesics do not suffice. This drug is available in hard tablet form with a potency of 30mg.
Do painful sensations affect your daily activities? Are you suffering from chronic pain conditions such as fibromyalgia or arthritis? Perhaps constant backaches deprive you of sleep? This informational page provides a comprehensive overview of dihydrocodeine. Its uses, side effects and precautions will be discussed to shed light on this potent medication.
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Dihydrocodeine is a medication often prescribed in the UK to alleviate pain. Physical pain is an unpleasant sensory feeling associated with tissue damage varying in intensity from mild to severe.
Acute pain lasts for a short period and is resolved once its cause is healed. It can result from cuts, broken bones or surgeries. Chronic aches usually last for a long time, more than 3 months, and may persist and return even when their cause is cured (arthritis, fibromyalgia and backaches).
Painful sensations can considerably affect the lives of sufferers. They impair mobility, result in sleep disturbances, cause stress and anxiety and lead to reduced overall quality of life. According to the survey published in the British Medical Journal, there are 28 million people in the UK, which is 43% of the populace, who suffer from chronic pain to some degree.
Dihydrocodeine has established itself as a reliable painkiller. It inhibits the transmission of pain signals in the central nervous system providing relief from moderate to severe aches, acute and chronic both. This drug allows people to regain their mobility, freely engage in daily activities and enjoy their lives.
Apart from alleviating pain, dihydrocodeine has also shown effectiveness in addressing severe dyspnea (shortness of breath) and suppressing coughing reflexes when other medications do not prove sufficient.
While taking opioids, it is important to stick with dosage instructions. They can be provided by a healthcare professional and must be strictly followed to minimize the risk of side effects and maximize the effectiveness of the drug.
The dose for dihydrocodeine may vary for different patients depending on the severity of pain, age and pre-existing medical conditions. It is typically recommended to start with 30mg taken every 4-6h as needed for pain management. This drug is advised to be taken with a full glass of water; it can be taken on an empty stomach or with food.
Its dose can be adjusted by a general practitioner or a consulting physician based on individual response. Geriatrics and those with liver/kidney issues may require lower doses. Exceeding 180mg a day is not recommended since it can increase the likelihood of adverse reactions.
Do not prolong the regimen with this medication unless it is instructed by a doctor. Dihydrocodeine has the potential to become habit forming, namely if misused. To discontinue the treatment, it is recommended to gradually taper off it to reduce withdrawal syndrome.
Dihydrocodeine is an opioid analgesic that mainly acts through the interaction with mu-opioid receptors located in the CNS, including the spinal cord and brain. When it attaches to these receptors, it prevents the passing of pain signals and also reduces the amount of neurotransmitters that are involved in the processing of pain.
It also reduces the feeling of aches and changes the way the brain processes it so that discomfort becomes milder. As well as being an effective analgesic, dihydrocodeine has sedative properties which can contribute to pain alleviation and may also cause drowsiness/sleepiness.
It is mainly eliminated by metabolism in the liver and is converted into several metabolites some of which also have analgesic effects. In general, dihydrocodeine acts on opioid receptors and the central nervous system to relieve pain and suppress coughing.
The onset of action of dihydrocodeine depends on several factors. They include whether the medication was taken on an empty stomach or not and individual metabolism. It usually kicks in within 30-60 minutes after the intake and reaches its peak of effectiveness in 1-2 hours.
Even though this drug can be taken with or without food, it is not recommended to ingest it with fatty meals because it can delay the onset. The duration of action of dihydrocodeine also depends on metabolism and may range from 4 to 6h.
Before you buy dihydrocodeine, it is recommended to consult with a healthcare professional. In combination with certain medicines and substances, it can cause potentially dangerous complications.
Mixing this opioid with alcoholic beverages can result in respiratory depression and excessive sedation. The same effects are reported in combination with this painkiller and other CNS depressants including benzodiazepines, muscle relaxants and sleep aids. Antidepressants and MAO inhibitors may result in serotonin syndrome and exacerbated side effects if mixed with dihydrocodeine.
Medications that affect the liver function can impact the metabolism of this drug altering its effectiveness. Some anticonvulsants may also interact with the medicine and affect how it works in the body. Do not combine dihydrocodeine with other opioids. It can increase the risk of adverse reactions.
A general practitioner must evaluate the concurrent medications before starting treatment with this drug. It will minimize the risks of undesirable interactions and ensure safe usage.
After ingestion, dihydrocodeine can be found in hair, urine, saliva and blood samples for some time. It is important to be aware of how long the medication stays in the system for some reasons. It helps to prevent drug interactions and it allows patients to maintain a consistent level of the substance in the blood to reach optimal therapeutic effect.
The half-life of a medicine is how long it takes for its concentration in the bloodstream to be reduced by half. The half-life of dihydrocodeine is around 3-5h depending on individual metabolism and the liver condition. It means that it takes this drug 1 to 3 days to be completely eliminated from the body.
Like in the case with any other medications, dihydrocodeine is associated with certain side effects. They are usually mild and manageable and not everyone will experience them. However, it is still vital to be aware of them and take measures if they become bothersome.
Common adverse reactions to this medicine include drowsiness/sedation, constipation, nausea, dry mouth, itching and rash. It is advisable to stay adequately hydrated and avoid activities that require full alertness and concentration if these effects occur. Nausea and stomach upset can be prevented by ingesting dihydrocodeine with a light meal or a snack.
Respiratory depression, confusion and mood changes may also arise, albeit extremely rarely. If side effects get strong or persist, it is recommended to address your concerns with a doctor. The specialist may titrate the dose to minimize them, provide advice on how to manage them or consider an alternative solution.
Dihydrocodeine has gone through an extensive evaluation process and is considered a safe and effective pain reliever. Before being marketed, medications have to undergo numerous clinical tests and trials. They need to demonstrate their safety profile and meet the stringent standards for efficacy set by regulatory bodies.
Food and Drug Administration (FDA) is a regulatory authority responsible for promoting public health by assessing and testing vaccines, medicines, food and other consumer products before they are sold to people. Dihydrocodeine has been licensed and approved by the FDA after assessment and is considered as safe if taken following the instructions.
Even so, this medication may not be suitable for everyone. It is contraindicated for patients with certain pre-existing medical conditions including respiratory depression, acute or severe asthma, severe liver impairment and hypersensitivity/allergy to the drug.
Pregnant/breastfeeding women, patients with bowel obstruction or people with a history of substance abuse should also avoid dihydrocodeine. Before starting treatment with this medication it is important to speak with your GP to confirm the drugs suitability.
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Last Reviewed: 15th October 2024
Next Review Due: November 2025
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