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Well-known by the brand name Soma, carisoprodol was created in the 1950s by the chemist Frank Berger of Wallace Laboratories in the United States. Valued for its rapid onset and perfect for short-term use, it was licensed and approved by the United States Food and Drug Administration (FDA) in 1959 and introduced to the market in the same year as a muscle relaxant.
It is part of a class of drugs known as skeletal muscle relaxants and is regarded for its low risk of addiction. Because of this, it is prescribed to treat both short term (acute) and long term (chronic) conditions. It is especially suitable for pain caused by muscle strain or joint conditions.
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Carisoprodol is an important medicine, used for a broad number of musculoskeletal conditions that many people suffer from. Based on research conducted in the UK on behalf of the government, it is estimated that some 20 million residents suffer from musculoskeletal conditions.
This prevalence can be explained by the fact that a lot of UK residents have sedentary lifestyles. Relatively few get enough exercise or observe good posture. Over years, most people get a bad back, might badly sprain their neck muscles, or get carpal tunnel syndrome (nerve compression of the wrist) which affects 14.4% of Britons.
According to the WHO, lower back pain is the single leading cause of disability in 160 countries. These conditions can become serious if not addressed in time. Musculoskeletal conditions are a threat to many, and having access to effective and affordable medicine lets millions of UK residents carry on with normal lives.
The dosage of carisoprodol should be determined by a doctor for each particular case, based on the patient's medical condition. This treatment has some sedative effects, like other muscle relaxant, so the sedation should be taken into account when dosage is determined.
It usually comes as 250 mg and 500 mg pills, and the starting dosage recommended in the UK generally is one or the other pill three times a day and at bedtime. Do not use this medicine for longer than the prescribed period.
Withdrawal symptoms similar to alcohol withdrawal are possible, so the dosage should never be change rapidly. Gradual adjustment is also important when stopping the medicine, as the user should taper off and never stop suddenly.
Carisoprodol is a central muscle relaxant. It means it works on the central nervous system to achieve muscle relaxation indirectly, without acting on the muscles. Interestingly, its exact action in the brain is unknown. It is assumed that the medication regulates the activity of neurons in the spinal cord and the brain. Through this process, pain signals are disrupted and disagreeable sensations are redefined. This is very effective for alleviating acute pain episodes.
Some believe that carisoprodol works in a similar way to benzodiazepines, amplifying the inhibitory neurotransmitter GABA. The transmitter's action brings down the activity of neurons, which leads to calm.
Some researchers note similarities between the action of carisoprodol and that of certain barbiturates. This is part of the reason why users taking any benzodiazepine or barbiturate drugs should avoid this treatment in most cases. The resulting combined effect can prove to be dangerous.
The effects of carisoprodol are usually felt within 30-60 minutes of administration. This time might not be the same for every user, with considerations related to metabolism, food in the stomach, and other factors affecting the onset time.
This quick onset time makes the treatment invaluable when fast relief is needed from pain caused by musculoskeletal disorders. The drug can quickly reduce muscle spasms and relieve the related pains. It can then be used to keep the pain from coming back. Overall, carisoprodol is considered the right treatment for acute pain episodes, where fast action is needed, but it can also be prescribed to manage chronic conditions.
One should stay away from taking carisoprodol with some medications where there is a possibility of the combination causing negative effects. It can further increase sedation when mixed with alcoholic beverages. This could have a negative effect on cognition and motor skills, which is dangerous as it may lead to accidents or injuries.
Concurrent use of other central nervous system depressants, benzodiazepines or opioids might lead to the same effect. This may result in over-sedation, lung problems and other alarming conditions. This means, in turn, that all users must carefully remember their conditions and medicines they are taking and relate them to a GP when the dosage is set.
Fatty or spicy food should be avoided with carisoprodol, as it might increase the risk of nausea in some users. The rare but possible side effects with this medicine will be covered in a later section. Users are advised to study a full list of contraindications before they start this medicine and only take it after consultation with their doctor or medical professional.
This treatment does not stay in the body for very long. It has a half life of approximately two to three hours on average, although, the duration for which carisoprodol remains in the body varies for different users. Metabolism, patient health and other physiological features all play a part on how long the medication will stay in the system.
The average time it takes for most drugs to leave the body completely is around five half-lives. Applied to carisoprodol, it means it will take 10 to 15 hours for the medicine to be completely eliminated from the body. Besides the user's state, other medications being taken concurrently may affect this time.
Carisoprodol is not a substance that will show up on standard drug tests. It has to be tested for specifically to be detected, and the test would also have to detect the drug's primary metabolite, meprobamate.
In a blood test, Soma might show up for about 24 hours after the last dose is ingested. In hair follicles, traces of the metabolites could be detected for about a month after the last time the medicine was used.
Carisoprodol may cause adverse effects. Although not every user will get them, it's still a good idea to be aware of them in case you encounter any. Drowsiness, dizziness and headaches are the three most often reported mild side effects. According to product labelling, about 17% of users felt sedation when taking it during trials.
Some other possible mild events are the appearance of cold sores, throat soreness, or swollen glands. This can be counteracted by OTC cold medicines and is not considered a severe adverse carisoprodol side effects. There are also some possible severe symptoms with this treatment, which occur much more rarely. Those include muscle spasms, irregular heartbeat and memory problems. These should be addressed with a medical professional as soon as possible.
Side effects can be avoided by observing the prescribed dosage and monitoring the use carefully. This is important when starting a treatment for the first time. There are some practices that can help avoid adverse effects. Drinking 2-3 litres of water daily can help with headaches. Light exercise, about 30 minutes a day, will help the body get used to the effects of carisoprodol faster.
As an authorised and certified drug, carisoprodol has undergone extensive research and testing. Clinical trials have been done to check the safety and efficacy of the medicine, and the results confirm its fine track record. The rigorous testing process in compliance with regulatory requirements ensures the safety of the medication for its intended use. The trials are conducted in multiple stages, on diverse groups of patients, and all adverse events are carefully recorded.
Studies done by research teams independent of governments are also available online and confirm the low incidence of side effects with carisoprodol. Overall, as long as the dosage recommendations are observed, this is considered to be a safe medicine.
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Last Reviewed: 15th October 2024
Next Review Due: November 2025
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